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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -Connexin 46, NT (Gap Junction alpha-3 Protein, Connexin-46, Cx46, GJA3)

Anti -Connexin 46, NT (Gap Junction alpha-3 Protein, Connexin-46, Cx46, GJA3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
GJA3, an integral membrane protein, belong to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and nonjunctional ('hemi-') channels. Defects in GJA3 are the cause of zonular pulverulent cataract type 3 (CZP3), a form of autosomal dominant congenital cataract.
Catalog #C7858-07D
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsELISA: 1:1000
Western Blot: 1:100-1:500
Immunohistochemistry (Paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to a portion of amino acids within aa115-145 near the N-terminal region of human Connexin 46, conjugated to KLH (NP_068773, Q9Y6H8).
SpecificityRecognizes human Connexin 46.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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