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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Contactin-associated protein 1 (Caspr1)

Anti -Contactin-associated protein 1 (Caspr1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
Contactin-associated protein 1(Caspr) is a single-pass type I membrane protein belonging to the neurexin family and is comprised of one F5/8 type C domain, one fibrinogen C-terminal domain, two EGF-like domains, and four laminin G-like domains. Caspr is well documented for its interaction with contactin, an interaction that is crucial to the transport of Caspr to the plasma membrane, the mylination of glial cells, and the generation of axoglial junctions. Studies also suggest that Caspr may play a regulatory role in the cell surface expression of contactin and its targeting to different axonal domains. Expression of Caspr is largely observed in the brain, mainly in CNS myelinated nerve fibers within paranodal axoglial junctions.
Catalog #C7865-19A
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry: 1:300 detects Caspr in rat cerebellum and rat hippocampus tissues.
Western Blot: 0.5ug/ml detected Caspr on 10ug of rat brain membrane tissue lysate.
Optimal dilutions to be determined by the researcher.
Positive ControlRat brain membrane tissue lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1k
Clone No11C235
HostMouse
SourceRat
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to rat Caspr.
SpecificityRecognizes rat Caspr. Species sequence homology: mouse 100%.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namescontactin associated protein 1, neurexin 4, neurexin-4 contactin-associated protein 1, Neurexin IV, Neurexin-4


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