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You are here:Home » Antibodies » Abs to Binding Proteins » Anti -CBFb (CBFB, Core Binding Factor beta)

Anti -CBFb (CBFB, Core Binding Factor beta)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH IC FC
CBFb is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family that master-regulates a host of proteins specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters (1).
Catalog #C7900-76C
ApplicationsSuitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry and Flow Cytometry. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000-1:10,000
Immunocytochemistry: 1:100-1:250
Immunohistochemistry: 1:100-1:250
Flow cytometry: 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone NoEPR6322
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in human CBFb
SpecificityRecognizes human CBFb. Species crossreactivity: Mouse and rat..
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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