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You are here:Home » Molecular Biology » MB-Binding Proteins » CBFB, aa1-182, Recombinant, Human (Core-binding Factor Subunit beta, CBF-beta, Polyomavirus Enhancer-binding Protein 2 beta Subunit, PEBP2-beta, PEA2-beta, SL3-3 Enhancer Factor 1 Subunit beta, SL3/AKV Core-binding Factor beta Subunit)

CBFB, aa1-182, Recombinant, Human (Core-binding Factor Subunit beta, CBF-beta,
Polyomavirus Enhancer-binding Protein 2 beta Subunit, PEBP2-beta, PEA2-beta, SL3-3
Enhancer Factor 1 Subunit beta, SL3/AKV Core-binding Factor beta Subunit)

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Specifications

CBFB, also known as PEBP2B, is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). This protein is a non-DNA binding regulatory subunit and it allosterically enhances DNA binding by alpha subunit.
Catalog #C7900-77
SourceRecombinant corresponding to aa1-182 of human CBFB protein, fused to His-tag at N-terminus, expressed in E.coli.
AA SequenceMGSSHHHHHH SSGLVPRGSH MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD GRSEIAFVAT GTNLSLQFFP ASWQGEQRQT PSREYVDLER EAGKVYLKAP MILNGVCVIW KGWIDLQRLD GMGCLEFDEE RAQQEDALAQ QAFEEARRRT REFEDRDRSH REEMEVRVSQ LLAVTGKKTT RP
Molecular Weight 23.6kD (202aa) confirmed by MALDI-TOF
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight23.6kD
SourceE.coli
Purity~85% (SDS-PAGE).
Concentration~0.5mg/ml
FormSupplied as a liquid in 20mM MES, pH 6.0, 0.1mM PMSF, 10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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