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You are here:Home » Antibodies » Antibodies-Actin Related Proteins » Anti -Cortactin (Src Substrate Cortactin, EMS1, Amplaxin, CTTN, Oncogene EMS1)

Anti -Cortactin (Src Substrate Cortactin, EMS1, Amplaxin, CTTN, Oncogene EMS1)


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Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Cortactin is a c-src substrate associated with sites of dynamic actin assembly at the leading edge of migrating cells promotes branched actin filament network formation by Arp2:3 complex. Cortactin is an F-actin-binding protein. The amino-terminal half of the protein is comprised of multiple copies of an internal, tandem 37aa repeat while the carboxyl-terminal half contains a distal SH3 domain. Cortactin, present in several different cell types, is enriched in cortical structures such as membrane ruffles and lamellipodia. The properties of cortactin indicate its importance for microfilament-membrane interactions as well as transducing signals from the cell surface to the cytoskeleton. Human cortactin gene is localized on chromosome 11q13.
Catalog #C7901-85L
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.01-0.03ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlMouse and Rat Brain lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to WKASAGHAVSIA-C, from the N-terminus of the protein sequence according to NP_005222.2; NP_612632.1.
SpecificityRecognizes mouse Cortactin. Species sequence homology: bovine, canine, human, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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