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You are here:Home » Antibodies » Abs to Actin Related Proteins » Anti -Cortactin (Src Substrate Cortactin, EMS1, Amplaxin, CTTN, Oncogene EMS1)

Anti -Cortactin (Src Substrate Cortactin, EMS1, Amplaxin, CTTN, Oncogene EMS1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Cortactin is a c-src substrate associated with sites of dynamic actin assembly at the leading edge of migrating cells promotes branched actin filament network formation by Arp2:3 complex. Cortactin is an F-actin-binding protein. The amino-terminal half of the protein is comprised of multiple copies of an internal, tandem 37aa repeat while the carboxyl-terminal half contains a distal SH3 domain. Cortactin, present in several different cell types, is enriched in cortical structures such as membrane ruffles and lamellipodia. The properties of cortactin indicate its importance for microfilament-membrane interactions as well as transducing signals from the cell surface to the cytoskeleton. Human cortactin gene is localized on chromosome 11q13.
Catalog #C7901-85L
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.01-0.03ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlMouse and Rat Brain lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to WKASAGHAVSIA-C, from the N-terminus of the protein sequence according to NP_005222.2; NP_612632.1.
SpecificityRecognizes mouse Cortactin. Species sequence homology: bovine, canine, human, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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