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Anti -Cortisol Binding Globulin (CBG, Corticosteroid Binding Globulin, Serine (or Cysteine) Proteinase Inhibitor Clade A (alpha-1 Antiproteinase, Antitrypsin) Member 6, Serpin Peptidase Inhibitor Clade A (alpha-1 Antiproteinase, Antitrypsin) Member 6, Serpin A6
Anti -Cortisol Binding Globulin (CBG, Corticosteroid Binding Globulin, Serine (or
Cysteine) Proteinase Inhibitor Clade A (alpha-1 Antiproteinase, Antitrypsin) Member 6,
Serpin Peptidase Inhibitor Clade A (alpha-1 Antiproteinase, Antitrypsin) Member 6, Serpin
A6
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| Serpin A6 (also corticosteroid-binding globulin/CBG and Transcortin) is a 45-60 kDa, secreted glycoprotein member of the clade A serpin family of protease inhibitors. Although it is a serpin family member, it shows no protease inhibition. Serpin A6 is produced principally by hepatocytes, but is also expressed by hypothalamic neurons and anterior pituitary endocrine cells. Serpin A6 transports progesterone and > 90% of circulating cortisol, and likely has three functions: first it can be cleaved, releasing cortisol to the tissues; second, it regulates levels of free hormone available over time; and third, it likely binds to specific cell-surface receptors when complexed to cortisol. Mature rat Serpin A6 is 374 amino acids (aa) in length (aa 23-396). It | | | contains an RCL segment that is involved in steroid binding (aa 334-351). Over aa 23-396, rat Serpin A6 shares 78% and 60% aa sequence identity with mouse and human Serpin A6, respectively. | | | Catalog # | C7904-25G | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilutions | Western Blot: 0.5ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Rat | | Concentration | ~0.2mg/ml (after reconstitution) | | Form | Supplied as a powder lyophilized from a solution containing PBS with 5% trehalose. Reconstitute to 0.2mg/ml with sterile PBS. | | Purity | Purified by immunoaffinity chromatography | | Immunogen | NS0-derived recombinant rat Serpin A6 (aa23-396) | | Specificity | Recognizes rat Serpin A6. Species Crossreactivity: < 5% cross-reactivity with rmSerpin A1, rmSerpin A5 and rhSerpin A4. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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