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You are here:Home » Antibodies » Abs to Prostaglandins » Anti -Cox-3 (COX1, Cox-1, COX3, PHS 1, Pghs1, PGHS-1)

Anti -Cox-3 (COX1, Cox-1, COX3, PHS 1, Pghs1, PGHS-1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans, COX-3 encodes proteins with completely different aa sequences than COX-1 or COX-2 and without COX activity. It has been suggested COX-3 as the key to unlocking the mystery of the mechanism of action of acetaminophen.
Catalog #C7904-73C2
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to mouse Cox-3 at N-terminus.
SpecificityRecognizes mouse Cox-3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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