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You are here:Home » Antibodies » Abs to Enzymes, Cyclooxygenase (COX) » Anti -COX 1 (Cyclooxygenase-1, PGHS-1, Prostaglandin Endoperoxide Synthase-1, PHS 1, Prostaglandin H2 synthase 1)

Anti -COX 1 (Cyclooxygenase-1, PGHS-1, Prostaglandin Endoperoxide Synthase-1, PHS 1,
Prostaglandin H2 synthase 1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX, COX 1 and COX 2. COX 1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL 1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX 2. COX 2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX-2.
Catalog #C7904-73G
Cellular Localization Cytoplasmic
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in TBS, pH 7.2, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide with sequence QDDGPAVERPSTEL, representing the C Terminus of the protein (residues 586-599) according to NP_000953; NP_542158.
SpecificityThis antibody is expected to recognize both human isoforms of this protein. Species Crossreactivity: Crossreacts with Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCyclooxygenase-1, PGHS-1, Prostaglandin Endoperoxide Synthase-1, PHS 1,Prostaglandin H2 synthase 1


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