Anti -COX 1 (Cyclooxygenase-1, PGHS-1, Prostaglandin Endoperoxide Synthase-1, PHS 1,
Prostaglandin H2 synthase 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B |
|
| Cyclooxygenase (COX), also known as prostaglandin H2 synthese and prostaglandin endoperoxide synthase, is an important enzyme in the conversion of arachidonic acid to prostaglandin H2.1, 2 Prostaglandin H2 is converted by other enzymes into inflammatory mediators such as prostaglandin (PG) D2, PGE2, PGF2a, PG12, and thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. COX consists of two isoforms, COX-I (599 amino acid residues) and COX-II (604 amino acid residues). | | | Catalog # | C7904-73J | | The COX enzymes, membrane-associated heme proteins that have cyclooxygenase and peroxidase activities, are targets of NSAID (nonsteroidal anti-inflammatory drugs) such as aspirin.3 COX-I is involved in the regulation of homeostatic functions throughout the body, such as vascular hemostasis, renal blood flow, and maintenance of glomerular function.4, 5, 6 It is constitutively produced in most cell types with high expression levels found in gastrointestinal tissues. COX-I is important in the gut for the production of prostaglandins, which inhibit gastric secretion. COX-I can be induced in monocytes, macrophages, and other cells as part of the inflammatory response by IL-1b and other cytokines. It is also induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. | | Cellular Localization | Cytoplasmic | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 8J1067 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | 0.08% Sodium Azide PBS, pH 7.4 | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Full length human COX-1. | | Specificity | Detects a band at approximately 70kD. Species Crossreactivity: Crossreacts with Human. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Cyclooxygenase-1, PGHS-1, Prostaglandin Endoperoxide Synthase-1, PHS 1,Prostaglandin H2 synthase 1 |
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