Anti -COX 1 (Cyclooxygenase 1, Cyclooxygenase-1, COX-1, COX1, Prostaglandin Endoperoxide
Synthase-1, Prostaglandin G/H Synthase 1, PGH Synthase 1, PGHS1, PGHS-1, Prostaglandin G/H
Synthase and Cyclooxygenase, Prostaglandin H Synthase 1, PHS 1, PHS1, PHS-1, Pros
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
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| Cyclooxygenase 1 (COX1), also known as Prostaglandin-endoperoxide synthase (PTGS1), is the key enzyme in prostaglandin biosynthesis. The gene was approximately 40kb long, with 11 protein-coding exons. There were 599aa residues with a calculated molecular mass of approximately 68kD. By analysis of a human/hamster somatic hybrid DNA panel, Funk et al. (1991) demonstrated that the PTGS1 gene maps to chromosome 9. Human prostaglandin endoperoxide synthase exhibited 91% aa identity with the sheep enzyme. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. | | | Catalog # | C7904-75D | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot (Human, mouse, rat): 0.1-0.5ug/ml | | Immunohistochemistry (paraffin)(Human): 0.5-1ug/ml. Antigen retrieval using heat is recommended. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml (after reconstitution) | | Form | Supplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to a sequence near the N-terminal, aa 35-52, CCYYPCQHQGICVRFGLD, of human COX1, different to the related rat and mouse sequence by 2aa. | | Specificity | Recognizes human COX 1. Species Cross-Reactivity: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -COX 1 (Cyclooxygenase 1, Cyclooxygenase-1, COX-1, COX1, Prostaglandin Endoperoxide Synthase-1, Prostaglandin G/H Synthase 1, PGH Synthase 1, PGHS1, PGHS-1, Prostaglandin G/H Synthase and Cyclooxygenase, Prostaglandin H Synthase 1, PHS 1, PHS1, PHS-1, Pros |
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