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Abs to Enzymes, Cyclooxygenase (COX)
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Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)
Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| Cyclooxygenase-2 (COX2) also known as prostaglandin G/H synthase 2 (PGHS2) is a 70kD microsomal enzyme that belongs to the prostaglandin G/H synthase family. It is inducibly-expressed by a number of cell types, including fibroblasts, vascular smooth muscle cells, endothelium, and monocytes. Functionally, COX2 is a homodimer that catalyzes two steps in the conversion of arachadonic acid to prostaglandin H 2. Mature human COX2 is 587 amino acids (aa) in length and contains one EGF-like domain (aa 18-55), a potential membrane interacting region (aa 277-292) and a globular catalytic domain (aa 293-604). At least one splice form exists that shows an 11 aa substitution for the C-terminal 451 amino acids. Mature human COX2 shows 87% aa identity to mouse COX2. | | | Catalog # | C7904-80F | | Applications | Suitable for use in Western Blot and ELISA. Other applications not tested. | | Recommended Dilution | Western Blot: 1ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | As reported | | Form | Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol, 0.02% SODIUM AZIDE. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | E. coli-derived recombinant human Cyclooxygenase 2 (aa18-604) SwissProt # P35354 | | Specificity | Recognizes human Cyclooxygenase 2. Species Crossreactivity: Mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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