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COX 2, Human, cDNA Probe (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)
COX 2, Human, cDNA Probe (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2,
PHS 2)
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| Prostaglandins are important regulators of immune responses, fever, and pain. Two isoforms of Prostaglandin H synthase are well characterized, namely COX1 (also called PGHS-1; PHS-1; Prostaglandin-endoperoxide synthase-1) and COX2 (also called PGHS-2; Prostaglandin-endoproxide synthase-2 and PHSII). Both forms of COX proteins are membrane associated heme proteins containing Cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Non steroidal anti-inflammatory drugs) such as aspirin. Cox-2 (rat/mouse/human 604aa) is homodimer of 70KD subunits (1). COX2 is induced by cytokines and mitogens. COX-2 may play an important role in regulating or promoting cell proliferation in some normal and nepotistic cells. It catalyzes arachidonate + AH(2) + 2 O(2) = Prostaglandin H2 + A + H(2)O. This enzyme acts both as a dioxygenase and as a peroxidase. It acts as the first step in the formation of prostaglandins and thromboxanes. Cox-2 contains 1 EGF-like domain. | | | Catalog # | C7904-80G | | Storage and Stability | Aliquot to avoid repeated freezing and thawing, and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months. | | Concentration | As reported | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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