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C7904-82F Mouse Anti-COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
P35354
Isotype
IgG1
Clone Number
6D318 (CX229)
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Hu Sh
Shipping Temp
Blue Ice
Storage Temp
-20°C

Cyclooxygenase catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of cyclooxygenase biosynthesis by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of cyclooxygenase, COX-2, is responsible for the biosynthesis of prostaglandins under acute inflammatory conditions.10 COX-2 is a 72kDa protein which has been cloned from a variety of species including human, mouse, rat, and sheep.

Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000 Immunohistochemistry: 1:100 Optimal dilution determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa580-599, NASSSRSGLDDINPTVLLKE of human COX-2. Species sequence homology: bovine and canine.
Form
Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide, 50% glycerol
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human COX-2. Species Crossreactivity: sheep. Does not crossreact with mouse, rat or rabbit COX-2 or COX-1.
Conjugates
Pricing
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