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You are here:Home » Antibodies » Abs to Enzymes, Cyclooxygenase (COX) » Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)

Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B IH IC
Cyclooxygenase catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of cyclooxygenase biosynthesis by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of cyclooxygenase, COX-2, is responsible for the biosynthesis of prostaglandins under acute inflammatory conditions.10 COX-2 is a 72kDa protein which has been cloned from a variety of species including human, mouse, rat, and sheep.
Catalog #C7904-82F
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml ( 1:1000)
Immunohistochemistry: 1:50-1:100
Optimal dilution determined by the researcher.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D318
HostMouse
SourceHuman
Concentration0.5mg/ml
FormSupplied as a lyophilized powder.Reconstitution: Reconstitute with 100ul sterile, ddH2O or sterile 40-50% glycerol.
PurityPurified.
ImmunogenSynthetic peptide corresponding to aa 580-599 of human COX-2.
(NASSSRSGLDDINPTVLLKE).
SpecificityRecognizes human COX-2. Species Crossreactivity: monkey and sheep. Does not crossreact with mouse, rat or rabbit COX-2 or COX-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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