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You are here:Home » Antibodies » Abs to Enzymes, Cyclooxygenase (COX) » Anti -COX 2 (PTGS2, Prostaglandin-endoperoxide Synthase 2, Prostaglandin G/H Synthase and Cyclooxygenase, COX2, COX-2, PHS-2, PGG/HS, PGHS-2, hCox-2, Prostaglandin G/H Synthase and Cyclooxygenase)

Anti -COX 2 (PTGS2, Prostaglandin-endoperoxide Synthase 2, Prostaglandin G/H Synthase and
Cyclooxygenase, COX2, COX-2, PHS-2, PGG/HS, PGHS-2, hCox-2, Prostaglandin G/H Synthase and
Cyclooxygenase)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Cyclooxygenase (COX) also known as PTGS catalyzes the conversion of arachidonic acid to prostaglandin H2 (PG), the common biosynthetic precursor to prostaglandins and thromboxane. The enzyme COX exists in two isoforms, encoded by distinct genes. COX-1 is constitutively expressed in most tissues, while COX-2 is primarily an inducible enzyme (constitutively expressed in brain and kidney), whose expression is activated in a variety of cells in response to cytokines, mitogens and endotoxins. COX2 exhibits 86%-89% aa sequence identity with mouse, rat, sheep, bovine, horse and rabbit PTGS2 proteins, respectively. It exists as homodimer with a molecular mass of approximately 70kD per monomer and each subunit composed of three distinct structural domains: a short N-terminal epidermal growth factor (EGF) domain; an alpha-helical membrane-binding motif; and a C-terminal catalytic domain. It acts as a major mediator of inflammation and plays a role in prostanoid signaling. It is expressed throughout the forebrain in discrete populations of neurons and is enriched in the cortex and hippocampus. The expression of Cox-2 gene is deregulated in epithelial tumors. The gene is mapped to human chromosome 1q25.2-q25.3.
Catalog #C7904-82G
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
ELISA: >1:32,000
Optimal dilutions to be determined by the researcher.
Positive ControlH460
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to NPTVLLKERSTEL, from C-terminus of the protein sequence according to NP_000954.
SpecificityRecognizes human COX2. Species sequence homology: bovine, equine, porcine, ovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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