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You are here:Home » Antibodies » Abs to Enzymes, Cyclooxygenase (COX) » Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)

Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH IC
COX catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of COX by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothosis that the inducible form of COX, COX-2, is responsible for the biosynthesis of prostaglandins under acute inflammatory conditions.1,2 COX-2 is a 72kD protein which has been cloned from a variety of species including human, mouse, rat, and sheep.
Catalog #C7904-82V
ApplicationsSuitable for use in Immunohistochemistry, Western Blot and Immunocytochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry: 1:300-1:600
Western Blot: 1:200
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in TBS, 0.5mg/ml BSA, 0.02% sodium azide and 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-terminal aa 570-598 (D570PQPTKTATINASASHSRLDDINPTVLIK598) of mouse/rat COX-2
SpecificityRecognizes mouse COX-2. Species Crossreactivity: human, rat, sheep, rabbit, monkey and guinea pig COX-2. Does not cross-react with COX-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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