Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH IC |
|
| COX catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of COX by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothosis that the inducible form of COX, COX-2, is responsible for the biosynthesis of prostaglandins under acute inflammatory conditions.1,2 COX-2 is a 72kD protein which has been cloned from a variety of species including human, mouse, rat, and sheep. | | | Catalog # | C7904-82V | | Applications | Suitable for use in Immunohistochemistry, Western Blot and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | | | Immunohistochemistry: 1:300-1:600 | | Western Blot: 1:200 | | Optimal dilution determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in TBS, 0.5mg/ml BSA, 0.02% sodium azide and 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-terminal aa 570-598 (D570PQPTKTATINASASHSRLDDINPTVLIK598) of mouse/rat COX-2 | | Specificity | Recognizes mouse COX-2. Species Crossreactivity: human, rat, sheep, rabbit, monkey and guinea pig COX-2. Does not cross-react with COX-1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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