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You are here:Home » Antibodies » Antibodies-Enzymes, Cyclooxygenase (COX) » Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)

Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
Catalog #C7904-82W2
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin):1:50-1:100 for 10 minutes at RT. Boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at RT for 20 minutes is required.
Immunohistochemistry: 1:10-1:1:500
Western Blot: 1:100-1:2000
Optimal dilutions to be determined by the researcher.
Positive ControlLung carcinoma and colon carcinoma
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
CAS NumberN/A
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 10mM sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant protein corresponding to the C-terminus of rat COX2. Cellular Localization: Microsomal membrane, cytoplasmic
SpecificityRecognizes rat COX 2 at ~70kD. Species Crossreactivity: human and mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCOX 2, COX2, Cyclooxygenase 2, Cyclooxygenase, Cyclooxygenase2, PGG/HS, PGH synthase 2, PGHS 2, PGHS2, PHS 2, PHS II, PHS2, PTGS2, Prostaglandin G/H synthase 2 precursor, Prostaglandin G/H synthase and cyclooxygenase, Prostaglandin G/H synthase, Prostagla


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