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You are here:Home » Antibodies » Abs to Enzymes, Cyclooxygenase (COX) » Anti -Cyclooxygenase-2 (PTGS2, Prostaglandin G/H Synthase 2, COX-2, PHS II, Prostaglandin H2 Synthase 2, PGH Synthase 2, PGHS-2, Prostaglandin-endoperoxide Synthase 2)

Anti -Cyclooxygenase-2 (PTGS2, Prostaglandin G/H Synthase 2, COX-2, PHS II, Prostaglandin
H2 Synthase 2, PGH Synthase 2, PGHS-2, Prostaglandin-endoperoxide Synthase 2)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B IH IC
Prostaglandin-endoperoxide synthase (fatty acid cyclooxygenase; PGH synthase; Cox-2) is a key enzyme in prostaglandin biosynthesis. The first rate-limiting step in the conversion of arachidonic acid to prostaglandins is catalyzed by Cox-1 and Cox-2. The cyclooxygenase activity of Cox-2 is inhibited by nonsteroidal antiinflammatory drugs such as aspirin and endomethacin. It is a mitogen-inducible gene (unlike Cox-1, which is a house-keeping gene), and this means it probably is a primary mediator of the inflammatory response.
Catalog #C7904-83L
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in TBS, pH 7.4, 50% glycerol, 0.1% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa578-596 from human PTGS2 (KLH).
SpecificityRecognizes human PTGS2. Species sequence homology: Mouse, rat and sheep.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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