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You are here:Home » Antibodies » Abs to Hormones, Steroids » Anti -C-Peptide (Hyperproinsulinemia, Insulin Precursor, Proinsulin)

Anti -C-Peptide (Hyperproinsulinemia, Insulin Precursor, Proinsulin)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E RIA
C-Peptide is part of the molecule of Proinsulin, that consists of three parts: C-Peptide and two long strands of amino acids (called the alpha and beta chains) that later become linked together to form the insulin molecule. From every molecule of proinsulin, one molecule of insulin plus one molecule of C-Peptide are produced. C-Peptide is released into the blood stream in equal amounts to insulin. A test of C-Peptide levels will show how much insulin the body is making. Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Although C-Peptide function is not fully understood, it binds to cell membranes which leads to increased intracellular Ca2++, K+ -ATPase and endothelial nitric oxide synthase activities. C-Peptide also functions in repair of the muscular layer of arteries.
Catalog #C7905-09C
ApplicationsSuitable for use in ELISA or RIA. Other applications have not been tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
HybridomaDerived from hybridization of X63-Ag8-653 myeloma cells with spleen cells of Balb/c mice immunized with recombinant C-peptide construction.
Affinity Constant(Kd) > 1x10e8
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No5E541
HostMouse
SourceHuman
Concentration~5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. before the addition of glycerol to 40%.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant C-peptide.
SpecificityBinds to the human free C-peptide and C-peptide region in proinsulin molecules. Antigenic determinants identified by Mab are in the three-dimensional structure generated by N- and C-terminal regions of C-peptide separated by beta-turn at position 47-50 of proinsulin. Not crossreactive with human, bovine, porcine and mouse/rat insulin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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