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Anti -C-Peptide (Hyperproinsulinemia, Insulin Precursor, Proinsulin)
Anti -C-Peptide (Hyperproinsulinemia, Insulin Precursor, Proinsulin)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E |
|
| C-peptide is a 31 amino acid peptide released when proinsulin is split into insulin and C-peptide. Proinsulin is split when it is released from the pancreas into the blood in response to a rise in serum glucose levels. C-peptide function is not fully understood, it binds to cell membranes which leads to increased intracellular Ca2++, K+ -ATPase and endothelial nitric oxide synthase activities. C-peptide also functions in repair of the muscular layer of arteries. Levels of C-peptide can be used to distinguish between type 1 and type 2 diabetes. Patients with type 1 diabetes will usually have decreased levels of C-peptide, while patients with type 2 diabetes will have normal or higher than normal levels. | | | Catalog # | C7905-10A | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: Can be used in indirect ELISA or as a dectection antibody in sandwich ELISA with C7905-01M. | | Optimal dilutions to be determined by the researcher. | | Hybridoma | Spleen cells from immunized Balb/c mice were fused with cells of the X63-Ag8-653 myeloma cell line. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9E33 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide. | | Purity | Purified by Protein A Chromatography. | | Immunogen | Recombinant C-Peptide. | | Specificity | Recognizes human C-Peptide. Does not cross-react with human, bovine, porcine, mouse or rat insulin. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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