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You are here:Home » Antibodies » Abs to Hormones, Steroids » Anti -C-Peptide I & II, CT (Hyperproinsulinemia, Insulin Precursor, Proinsulin)

Anti -C-Peptide I & II, CT (Hyperproinsulinemia, Insulin Precursor, Proinsulin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
C-Peptide is part of the molecule of Proinsulin, that consists of three parts: C-Peptide and two long strands of amino acids (called the alpha and beta chains) that later become linked together to form the insulin molecule. From every molecule of proinsulin, one molecule of insulin plus one molecule of C-Peptide are produced. C-Peptide is released into the blood stream in equal amounts to insulin. A test of C-Peptide levels will show how much insulin the body is making. Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Although C-Peptide function is not fully understood, it binds to cell membranes which leads to increased intracellular Ca2++, K+ -ATPase and endothelial nitric oxide synthase activities. C-Peptide also functions in repair of the muscular layer of arteries.
Catalog #C7905-20B
ApplicationsSuitable for use in ELISA. Other applications have not been tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
HybridomaSp2/0 myeloma cells with spleen cells from Balb/c mice
Matched PairsFor immunoassay to detect Rat C-peptides I and II. Crossreactivity of the recommended pair with native rat proinsulin is <0.1%.
Capture: C7905-20B Detection: C7905-19A
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J87
HostMouse
SourceRat
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein A chromatography. (>90% pure (SDS-PAGE).
ImmunogenSynthetic peptide fragments of rat C-peptides I and II conjugated with a carrier protein
SpecificityRecognizes C-terminal of rat C-peptide I and II. Cross reacts with mouse C-peptide I. Weak crossreactivity with mouse C-peptide II. Does not crossreact with rat proinsulin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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