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You are here:Home » Antibodies » Abs to Binding Proteins » Anti -CRABP I (Cellular Retinoic Acid Binding Protein I)

Anti -CRABP I (Cellular Retinoic Acid Binding Protein I)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse E B IH
Retinoic acid (RA), a metabolite of vitamin A, plays an important role in growth and differentiation by modulation of expression of certain genes. RA functions through its interaction with the nuclear protein, retinoic acid receptor (RAR) and the 9-cis RA with retinoid X receptor (RXR). The Cellular Retinoic Acid Binding Proteins (CRABP) bind RA with a high affinity and belong to the family of fatty acid binding proteins. Two forms of CRABP have been characterized, CRABP 1 and CRABP 2 which share ~75% sequence conservation. The main role of CRABP 1 may be to protect retinoids from non-specific dehydrogenases and direct them to specific enzymes. The precise role of CRABP 2 is still poorly understood but it seems to play a role in the interaction of ligands (RA, 9-cis RA) with nuclear receptors (RAR/RXR).
Catalog #C7906-70B
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry (Fr). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No8J983
HostMouse
SourceBovine
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
PurityAscites
ImmunogenOxidized CRABP 1 from bovine retina.
SpecificityDetects cellular Retinoic Acid Binding Protein 1 (CRABP 1). This antibody does not crossreact with Cellular Retinol Binding Protein (CRBP), performic acid oxidized CRBP, interphotoreceptor retinoid binding protein or retinol binding protein. Species Crossreactivity: Crossreacts with Human, Rabbit, Rat, bovine, Cat, Chicken, Primate and Reptiles.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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