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You are here:Home » Antibodies » Abs to Carbohydrates, Glycoproteins » Anti -Cranin (Dystroglycan)

Anti -Cranin (Dystroglycan)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E IH IC
Cranin is expressed in brain and many other tissues, it binds laminin with high affinity in a calcium dependent manner. It appears to be important in maintaining normal muscle integrity. Loss of cranin from the muscle surface may be one of the primary events leading to muscle injury in congenital muscular dystrophies, it may also play a role in the cognitive deficits often seen in such conditions.
Catalog #C7906-75
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Immunocytochemistry. Not recommended for use in Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry: 1:1-1:50 detects Cranin on tissue fixed briefly with 0.5% glutaraldehyde, 4% paraformaldehyde, methanol or acetone. Prolonged fixation must be avoided.
Immunocytochemistry: Neuron, astrocyte, smooth muscle, fibroblast and epithelial cell lines.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM
Clone No2Q36
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid.
PurityAscites
ImmunogenSynthetic peptide corresponding to aa572-604 of human Cranin.
SpecificityRecognizes human Cranin (dystroglycan), extracellular site, near the C-terminus of the alpha-subunit. The expression and localization of cranin varies considerably according to the cells physiologic state and differentiaion state. Species Crossreactivity: rat, mouse, sheep, chicken and Xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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