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You are here:Home » Antibodies » Abs to Cardiac Markers » Anti -C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1)

Anti -C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
C-reactive protein (CRP) is an acute phase reactant. CRP is released by the body in response to acute injury, infection, or other inflammatory stimuli. Recent development of a high sensitivity assay for CRP (hs-CRP) has enabled investigation of this marker of systemic inflammation.
Atheromatous plaques in diseased arteries typically contain inflammatory cells. Rupture of atheromatous plaque is thought to be the mechanism for acute myocardial infarction and acute coronary syndrome. The most common site of plaque rupture appears to be the shoulder region where inflammatory cells are most prominent. Thus the release of acute phase reactants as a response to inflammation have been proposed as a potential marker of an "unstable" atheromatous plaque and underlying atherosclerosis.
Studies have shown a positive association between CRP and coronary artery disease. In a survey of 388 British men aged 50-69, the prevalence of coronary artery disease increased 1.5 fold for each doubling of CRP level.
Multiple prospective studies have also demonstrated that baseline CRP is a good marker of future cardiovascular events and may also be a good marker of cardiovascular risk in addition to lipid levels.
Catalog #C7907-07
ApplicationsSuitable for use in ELISA, CRP immunoassay, as a coating antibody and in immunoaffinity purification. Other applications have not been tested.
Recommended DilutionELISA: Titer: > 10e-6
Optimal dilutions to be determined by the researcher.
HybridomaHybridization of Sp 2/0 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No1.BB.95
HostMouse
SourceHuman
Concentration~2mg/ml
FormSupplied in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
PurityChromatography on protein A Sepharose.
ImmunogenPurified Human CRP
SpecificityReacts with human C-Reactive Protein (CRP).
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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