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You are here:Home » Antibodies » Abs to Cardiac Markers » Anti -C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1)

Anti -C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
C-reactive protein (CRP) is an acute phase reactant. CRP is released by the body in response to acute injury, infection, or other inflammatory stimuli. Recent development of a high sensitivity assay for CRP (hs-CRP) has enabled investigation of this marker of systemic inflammation.
Catalog #C7907-09
CRP and AtherosclerosisAtheromatous plaques in diseased arteries typically contain inflammatory cells. Rupture of atheromatous plaque is thought to be the mechanism for acute myocardial infarction and acute coronary syndrome. The most common site of plaque rupture appears to be the shoulder region where inflammatory cells are most prominent. Thus the release of acute phase reactants as a response to inflammation have been proposed as a potential marker of an "unstable" atheromatous plaque and underlying atherosclerosis. Studies have shown a positive association between CRP and coronary artery disease. In a survey of 388 British men aged 50-69, the prevalence of coronary artery disease increased 1.5 fold for each doubling of CRP level (1). Multiple prospective studies demonstrated that baseline CRP is a good marker of future cardiovascular events (2). It has been suggested that CRP may be a good marker of cardiovascular risk in addition to lipid level.
ApplicationsSuitable for use in CRP immunoassay and immunoaffinity purification, and as coating/tracer antibody in ELISA. Other applications have not been tested.
Recommended DilutionELISA: > 10e-6 (Titer)
Optimal dilutions to be determined by the researcher.
HybridomaSp 2/0 myeloma cells with spleen cells from Balb/c mice.
Matched PairSuitable for use as the capture or solid phase antibody.
Matched to C7907-10 or C7907-11 as the detection or conjugate (label) antibody.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No1.BB.97
HostMouse
SourceHuman
Concentration~3mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide, before the addition of glycerol to 40%.
PurityPurified by Protein A affinity chromatography. Purity is tested by electrophoresis (> 90%).
ImmunogenPurified Human CRP
SpecificityRecognizes human CRP. Recognizes antigen both in the presence and in the absence (samples containing EDTA) of Ca2+.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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