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You are here:Home » Antibodies » Abs to Cardiac Markers » Anti -C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1) (HRP)

Anti -C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1) (HRP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified
Pentraxins family of proteins acquired the name from their ability to form pentameric (or decameric) structures formed by non-covalent interactions. C-reactive protein (CRP or PTX1; mature chain 206 aa; chromosome 1q21-23) nonglycosylated, ~24kD monomer and ~118kD pentamer) is a ubiquitous protein found in both vertebrates and invertebrates. Originally CRP was defined as a substance, observed in the plasma of patients with acute infections, that reacted with the C polysaccharide of the Pneumococcus. It is one of the plasma proteins that are called acute phase reactants because of a pronounced rise in concentration after tissue injury or inflammation. In the case of CRP the rise may be 1000-fold or more. CRP is composed of 5 identical, 21,500MW subunits. It is detectable on the surface of about 4% of normal peripheral blood lymphocytes. Acute phase reactant CRP is produced in the liver. Those cells produce CRP detectable on lymphocytes.
Catalog #C7907-21K
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:25,000
Western Blot: 1:50-1:500
Optimal dilutions to be determined by the researcher.
Molar Ratio of Enzyme to Antibody~4:1
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceRat
Concentration~0.5mg/ml
FormSupplied as a liquid in 50mM HEPES, pH 7.1, 0.1 M sodium chloride, 0.2% BSA, 0.01% Thimerosal before the addition of 40% glycerol. Labeled with horseradish peroxidase (HRP).
Purity95% Purified by immunoaffinity chromatography.
ImmunogenCRP was immunoaffinity purified from rat serum.
SpecificitySpecific for rat CRP. No reactivity is observed with SAP or other pentraxins. Species crossreactivity: Minimal crossreactivity with mouse and human CRP. For anti-human CRP, see Cat# C7907-21G.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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