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You are here:Home » Antibodies » Abs to Disease Markers » Anti -CREB (CBP, CREBBP, CREB binding protein, cAMP Response Element Binding Protein, RTS, RSTS, Rubinstein-Taybi syndrome)

Anti -CREB (CBP, CREBBP, CREB binding protein, cAMP Response Element Binding Protein, RTS,
RSTS, Rubinstein-Taybi syndrome)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
The transcription factor cAMP response element binding (CREB) binds the palindromic octanucleotide TGACGTCA (8,9). Members of ATF/CREB family include CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3 (3-7). These proteins share highly conserved leucine zipper dimerization and basic DNA binding domains at the COOH terminal but are highly divergent in their amino terminal domains (5). CREB-1 is phosphorylated at Ser133, a key regulatory site controlling transcriptional activity, by many different kinases including protein kinase A, the calmodulin-dependent protein kinase CaMKII, p44/42 MAP kinase, p90RSK, p38 MAP kinase and MSK1 (2). Phosphorylation allows recruitment of CREB-binding protein (CBP), a large co-activator that contacts the general transcriptional machinery. CREB-mediated transcription regulates diverse cellular responses, including intermediary metabolism, neuronal signaling, cell proliferation, and apoptosis (1).
Catalog #C7915-01H
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J1080
HostMouse
ConcentrationAs reported
FormPBS containing 0.2% gelatin, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
SpecificityIn HeLa, a 43kD band is observed. Species Crossreactivity: Human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCBP, CREBBP, CREB binding protein, cAMP Response Element Binding Protein, RTS, RSTS, Rubinstein-Taybi syndrome


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