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You are here:Home » Antibodies » Antibodies-Disease Markers » Anti -CREB, phosphorylated (Ser121) (CREB1, CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1)

Anti -CREB, phosphorylated (Ser121) (CREB1, CREB-1, Cyclic AMP-responsive element-binding
protein 1, cAMP-responsive element-binding protein 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. CREB is also regulated by DNA-damaging stimuli and is directly phosphorylated on Ser-121 by the ataxia-telangiectasia-mutated protein kinase, ATM in response to ionizing radiation.
Catalog #C7915-01J
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.3mg/ml
FormSupplied as a liquid in Tris buffer containing 50% glycerol and 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenA phospho-peptide spanning the Ser-121 phosphorylation site of human CREB1, UniProt Accession #P16220
SpecificityThis antibody is specific for the Ser-121-phosphorylated form of CREB1. Species Crossreactivity: Reacts with human and mouse CREB1. Other species have not been tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCREB1, CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1


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