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You are here:Home » Antibodies » Abs to G Protein Receptors » Anti -CRTH2 (Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CD294, CD294 Antigen, DL1R, G Protein-coupled Receptor, GPCR GPR44, GPR44, Putative G Protein Coupled Receptor 44)

Anti -CRTH2 (Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CD294,
CD294 Antigen, DL1R, G Protein-coupled Receptor, GPCR GPR44, GPR44, Putative G Protein
Coupled Receptor 44)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells.
Catalog #C7916-05G
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human CRTH2.
SpecificityRecognizes human GPR44. Species sequence homology: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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