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Anti -CRIM1 (Cysteine-rich Motor Neuron 1 Protein, Cysteine-rich Transmembrane BMP Regulator 1 (Chordin-like), CRIM 1, CRIM-1, Cysteine-rich Repeat-containing Protein S52, MGC138194, Processed Cysteine-rich Motor Neuron 1 Protein, S52) (Azide Free)
Anti -CRIM1 (Cysteine-rich Motor Neuron 1 Protein, Cysteine-rich Transmembrane BMP
Regulator 1 (Chordin-like), CRIM 1, CRIM-1, Cysteine-rich Repeat-containing Protein S52,
MGC138194, Processed Cysteine-rich Motor Neuron 1 Protein, S52) (Azide Free)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH |
|
| Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed Sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]). | | | Catalog # | C7921-90 | | Applications | Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Immunohistochemistry (paraffin): 1.5ug/ml | | ELISA: 1ug/ml-3ng/ml | | Optimal dilutions to be determined by the researcher. | | Hybridoma | Sp2/0 myeloma cells with spleen cells from Balb/c mice. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 10B2602 | | Host | Mouse | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free). | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Recombinant protein corresponding to a portion of amino acids within aa36-146 of human CRIM1. | | Specificity | Recognizes human CRIM1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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