Anti -Crk p38 phosphorylated, (Tyr221) (Adapter molecule crk, Avian sarcoma virus CT10 (v
crk) oncogene homolog, CRK isoform 2, CRK isoform II, CRKII, p38Proto oncogene C crk, v
crk avian, Sarcoma virus CT10 oncogene homolog, v crk Sarcoma virus CT10 oncogene h
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IC |
|
| Crk (p38) are adaptor proteins, composed mostly of SH2 and SH3 domains, which play a key role in cellular signaling by mediating the construction of protein complexes and also by managing cell proliferation, differentiation, and migration (1). They are critical integrators | | | of upstream signals for cell invasion and migration in human cancer cell lines. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been | | | observed in multiple human cancers (2). In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth (3). Crk | | | associates with ERM family proteins (including ezrin, radixin, and moesin), activates RhoA, and promotes cell motility toward hyaluronic acid (4). | | | Catalog # | C7924-10C | | Applications | Suitable for use in Immunocytochemistry, Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-2000 | | Immunocytochemistry: 1:50 -10 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9E231 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA. | | Purity | Supernatant | | Immunogen | A synthetic phospho peptide corresponding to region surrounding Tyrosine 221. | | Specificity | Recognizes human Crk/p38 protein when phosphorylated at Tyr211. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
