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You are here:Home » Antibodies » Abs to Disease Markers » Anti -Crk p38 phosphorylated, (Tyr221) (Adapter molecule crk, Avian sarcoma virus CT10 (v crk) oncogene homolog, CRK isoform 2, CRK isoform II, CRKII, p38Proto oncogene C crk, v crk avian, Sarcoma virus CT10 oncogene homolog, v crk Sarcoma virus CT10 oncogene h

Anti -Crk p38 phosphorylated, (Tyr221) (Adapter molecule crk, Avian sarcoma virus CT10 (v
crk) oncogene homolog, CRK isoform 2, CRK isoform II, CRKII, p38Proto oncogene C crk, v
crk avian, Sarcoma virus CT10 oncogene homolog, v crk Sarcoma virus CT10 oncogene h

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IC
Crk (p38) are adaptor proteins, composed mostly of SH2 and SH3 domains, which play a key role in cellular signaling by mediating the construction of protein complexes and also by managing cell proliferation, differentiation, and migration (1). They are critical integrators
of upstream signals for cell invasion and migration in human cancer cell lines. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been
observed in multiple human cancers (2). In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth (3). Crk
associates with ERM family proteins (including ezrin, radixin, and moesin), activates RhoA, and promotes cell motility toward hyaluronic acid (4).
Catalog #C7924-10C
ApplicationsSuitable for use in Immunocytochemistry, Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-2000
Immunocytochemistry: 1:50 -10
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E231
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
PuritySupernatant
ImmunogenA synthetic phospho peptide corresponding to region surrounding Tyrosine 221.
SpecificityRecognizes human Crk/p38 protein when phosphorylated at Tyr211.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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