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You are here:Home » Antibodies » Abs to Disease Markers » Anti -CrkL, phosphorylated (Tyr207), (Crk-like protein, v-crk sarcoma virus CT10 oncogene homolog (avian)-like)

Anti -CrkL, phosphorylated (Tyr207), (Crk-like protein, v-crk sarcoma virus CT10 oncogene
homolog (avian)-like)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP
CrkL (Crk-like), a 36kD protein predominantly expressed in hematopoietic cell lines, is a member of the Crk adapter protein family. Lacking any intrinsic enzymatic activity, CrkL is composed of one SH2 domain and two SH3 domains (1). The SH2 domain of CrkL as been shown to interact with c-Cbl, Cas, Hef-1 and Paxillin (2); while the N-terminal SH3 can bind to c-ABL, Sos1 and C3G (3). Additionally, the phosphorylated form of CrkL (pY207) binds to BCr-ABL oncogene in chronic myelogenous leukemia cells (4).
Catalog #C7924-10D
ApplicationsSuitable for use in Western Blot, Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:10,000
Immunoprecipitation: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E232
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
PuritySupernatant
ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Tyr207 of human CrkL.
SpecificityRecognizes human CrkL phosphorylated on Tyrosine 207.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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