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You are here:Home » Antibodies » Abs to Disease Markers » Anti -CrkL, phosphorylated (Tyr207) (Crk-like Protein, v-crk sarcoma virus CT10 oncogene homolog (avian)-like)

Anti -CrkL, phosphorylated (Tyr207) (Crk-like Protein, v-crk sarcoma virus CT10 oncogene
homolog (avian)-like)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
CRKL is a 39kD adaptor protein with one SH2 and two SH3 binding domains. CRKL is the major protein which is tyrosine phosphorylated in response to BCR/ABL (chronic myelogenous leukemia) and growth factor activation. In myeloid cells, it binds to proteins such as paxillin, p130cas and p120 cbl. CRKL aslo appears to bind ABL and SOS.
Catalog #C7925-50D
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:2000
Optimal dilutions to be determined by the researcher.
Positive ControlK562 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H223
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.05% sodium azide.
PuritySupernatant.
ImmunogenSynthetic peptide surrounding phosporykated tyrosine amino acid 207 of human CRKL. Epitope: Phosphorylated Tyr207
SpecificityRecognizes phosphorylated human CRKL. Species sequence homology: mouse and rat (100%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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