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You are here:Home » Antibodies » Abs to Binding Proteins » Anti -Csk Binding Protein (CBP, PAG, Phosphoprotein Associated with GEMs)

Anti -Csk Binding Protein (CBP, PAG, Phosphoprotein Associated with GEMs)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified B IP
Csk binding protein, also known as PAG (phosphoprotein associated with GEMs), is a ubiquitously expressed 46kD transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80kD molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.
Catalog #C7945-16H
Applications
Suitable for use in Immunoprecipitation and Western Blot.
Other applications have not been tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
Purity95% SDS-PAGE
ImmunogenRecombinant intracellular fragment corresponding to aa 97-432 of human PAG/Cbp (phosphoprotein associated with GEMS/Csk-binding protein).
SpecificityRecognizes human PAG/Cbp. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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