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You are here:Home » Antibodies » Abs to Disease Markers » Anti -CSL (CBF1, RBP-Jk, J kappa-Recombination Signal-Binding Protein, Suppressor of Hairless, Lag-1)

Anti -CSL (CBF1, RBP-Jk, J kappa-Recombination Signal-Binding Protein, Suppressor of
Hairless, Lag-1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
RBP-jk, Recombinant signal binding protein for immunoglobin kappa J region, is a human homolog for the Drosophila gene, suppressor of hairless. RBP-jk is located in the nucleus and is a 60kD monomeric protein that is used as a promoter region in notch signaling. Notch signaling is important in cell to cell communication which allows "a differentiating cell to suppress the same differentiation fate in a neighboring cell (the receiving cell). This ensures that the correct number of cells are distributed to distinct cell fates." When RBP-jk is not associated with Notch proteins, it acts as a transcriptional repressor. A disease associated with RBP-jk is the Epstein Barr virus.
Catalog #C7945-35A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlHepG2 and mouse liver cell lysates.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.05% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic Linear peptide corresponding to the Beta-Trefoil Domain a.a. 194-206 of RBP-jk (KLH).
SpecificityRecognizes the Beta-Trefoil Domain of human and mouse RBP-jk. Species sequence homology: Drosophila, Hydra, Horse, rat, Danio, and chicken.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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