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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -CTDSP1, CT (V250) (Carboxy-terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 1, Nuclear LIM Interactor-interacting Factor 3, NLI-interacting Factor 3, NLI-IF, NIF3, NLIIF)

Anti -CTDSP1, CT (V250) (Carboxy-terminal Domain RNA Polymerase II Polypeptide A Small
Phosphatase 1, Nuclear LIM Interactor-interacting Factor 3, NLI-interacting Factor 3,
NLI-IF, NIF3, NLIIF)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B IH
CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.
Catalog #C7947-98A
ApplicationsSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide selected from the C-terminal region of human CTDSP1-V250 protein (KLH).
SpecificityRecognizes human CTDSP1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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