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You are here:Home » Antibodies » Abs to Cullin » Anti -Cullin 1 (CT) (CUL-1)

Anti -Cullin 1 (CT) (CUL-1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IP
Cullin proteins assemble a large number of RING E3 ubiquitin ligases and regulate various physiological processes. It has been shown that the SKP1, CUL1, F-box (SCF) containing pathway, although similarly used by the mammalian CUL1, is not shared by other cullin members. This implies that most cullins may use a SKP1/F-box-independent pathway to facilitate protein degradation. The majority of CUL1 has been found in a complex with CAND1 and ROC1, independent of SKP1 and F-box protein SKP2. Data suggests that CAND1 regulates the formation of the SCF complex, and its dissociation from CUL1 is coupled with the incorporation of F-box proteins into the SCF complex, causing their destabilization.
Catalog #C7949-01H
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:2,000-1:10,000
Western Blot: 1:500-1:1,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.01% sodium azide.
PurityPurified by delipidation and defibrination.
ImmunogenSynthetic peptide, DGEKDTYSYLA, corresponding to aa766-776 of human Cul1, C-terminus (KLH).
SpecificityRecognizes human Cullin 1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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