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You are here:Home » Antibodies » Abs to Cullin » Anti -Cullin 3 (NT) (CUL-3)

Anti -Cullin 3 (NT) (CUL-3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IP
CUL-3 is a member of the family of human cullin genes (CUL-1,-2,-3,-4a,-4b, and-5), homologous to the S. cerevisiae cdc53 gene. Cullin-3 is proposed to be a part of E3 protein-ubiqutinnn ligase. It forms a tight complex with cyclin E and targets it for ubiquitination, which leads to its degradation by protesomes. Cyclin E is an activator of cdk2, which leads the cell to S phase. Cul-3-/-mice show increased accumulation of Cyclin E protein and disruption of normal cell cycle regulation in vivo. Thus Cullin-3 is important in the regulation of S phase of cell cycle.
Catalog #C7949-20F
ApplicationsSuitable for use in ELISA, Western Blot, Immunoprecipitation. Other applications not tested.
Recommended DilutionELISA: 1:2000-1:10,000
Western blot: 1:500-1:1,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.01% sodium azide.
PuritySerum
ImmunogenSynthetic peptide, MSNLSKGTGSRK, corresponding to aa1-12 of human Cul3, N-terminus (KLH).
SpecificityRecognizes human Cullin 3 at ~88.9kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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