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You are here:Home » Antibodies » Abs to Cullin » Anti -Cullin 3, NT (CUL3, Cullin-3, CUL-3, KIAA0617)

Anti -Cullin 3, NT (CUL3, Cullin-3, CUL-3, KIAA0617)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IP IH
Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3. Component of an ubiquitin-protein E3 ligase complex which includes at least CUL3 and KLHL12. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A.
Catalog #C7949-21C
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:2000-1:10,000
Western Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.01% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa1-12 of human Cullin 3 at N-terminal (KLH).
SpecificityRecognizes human Cullin 3. Species sequence homology: Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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