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You are here:Home » Antibodies » Abs to Cullin » Anti -CUL5, NT (VACM-1, Vasopressin-activated calcium-mobilizing receptor, Cullin-5, CUL-5, CUL5, VACM1)

Anti -CUL5, NT (VACM-1, Vasopressin-activated calcium-mobilizing receptor, Cullin-5,
CUL-5, CUL5, VACM1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IP IH
CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55kD protein and may form a cell surface vasopressin receptor.
Catalog #C7949-21N4
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
ELISA: 1:2000-1:10,000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.01% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa4-18 of human Cullin 5 at N-terminal (KLH).
SpecificityRecognizes human Cullin 5. Species sequence homology: Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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