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Abs to Cullin
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Anti -Cullin 7 (CUL-7, p185, KIAA0076, Cullin homolog 7, p180)
Anti -Cullin 7 (CUL-7, p185, KIAA0076, Cullin homolog 7, p180)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP |
|
| Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyze polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 7 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 7 seems to be involved in proteosomal degradation of proteins involved in endothelial proliferation and/or differentiation. Cullin 7 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Cullin 7 interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone. | | | Catalog # | C7949-22B | | Applications | Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | As reported | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | A synthetic peptide which maps to a region between residues 1500 and 1550 of human Cullin homolog 7 using the numbering given in SwissProt entry Q14999 (GeneID 9820). | | Specificity | Specific for human Cul7 protein. Species Crossreactivity: Human & mouse. Other species have not been tested. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Cul7, Cul-7, Cullin-7, Cullin homolog 7, p185, p180, KIAA0076 |
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