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You are here:Home » Biochemicals » Biochem-Inhibitors » Curcumin (Curcuma Longa, 1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane)

Curcumin (Curcuma Longa, 1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione,
Diferuloylmethane)

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Specifications

Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC50=8uM) and cyclooxygenase (COX) (IC50=52uM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC50 of ~25uM. Does not affect p300/CREB binding protein-associated factor (PCAF).
Catalog #C7980-80
SolubilityDMSO (25mg/ml) or EtOH (10mg/ml)
Molecular Weight~368.38
CAS Number458-37-7
Molecular FormulaC H O
Molecular Weight~368.38
Purity~98% (¹H NMR)
ConcentrationNot determined
FormSupplied as a orange-yellow solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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