CX3CR1 is a 40kD member of the delta-group of rhodopsin GPCRs. It is expressed on astrocytes, microglia, macrophages, Th1 and Tc1 T cells, NK cells, mouse Gr1lo monocytes plus smooth muscle and mast cells. CX3CR1 mediates adhesion to fractalkine, promotes avid binding of integrins to their ligands, and extends the life of monocytes. Mouse CX3CR1 is a 7-transmembrane protein that is 354aa in length. It contains a 32aa N-terminal extracellular region that shows no glycosylation, and a 56aa C-terminal cytoplasmic domain. Over aa1-32, 91-104, 169-196 and 258-274 collectively, mouse CX3CR1 shares 96% and 77% aa identity with rat and human CX3CR1, respectively.
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