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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -CXCR3 (CD183)

Anti -CXCR3 (CD183)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH FC
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Historically, CD183 was the third CXC chemokine receptor discovered and therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. The CXC chemokine receptor 3 (CXCR3), a G-protein-coupled 7-transmembrane receptor, is expressed at high levels on activated and memory T cells, B cells, natural killer cells, and plasmacytoid monocytes.
Catalog #C8349-03B
ApplicationsSuitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: Paraffin sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J1096
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman CXCR3 transfected NSO mouse myeloma cells.
Cellular LocalizationIntegral membrane protein
SpecificityRecognizes human CXCR3 transfected cells. Does not react with the parent cell line by flow cytometry. Does not crossreact with human CXCR1, CXCR2 and CXCR4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCKR-L2, CMKAR3, GPR9, IP10, IP10-R, Mig-R, MigR


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