Anti -CXCR3 (C-X-C Chemokine Receptor Type 3, CXC-R3, CXCR-3, CKR-L2, G Protein-coupled
Receptor 9, Interferon-inducible Protein 10 Receptor, IP-10 Receptor, CD183, GPR9)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E |
|
| CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10, Mig and I-TAC. The protein is mainly expressed on activated Th1 cells, B cells and natural killer cells. It is activated by the interferon-gamma-inducible chemokines CXCL9, CXCL10 and CXCL11, with CXCL11 having the highest affinity. Upon activation, CXCR3 activates pertussis toxin-sensitive G proteins of the Galphai class and mediates, among others, chemotaxis, calcium flux and activation of kinases such as p44/p42 MAPK and Akt. The protein and its ligands are upregulated in a wide variety of inflammatory diseases, implying a role for CXCR3 in serious disorders (e.g. rheumatoid arthritis, multiple sclerosis, transplant rejection, atherosclerosis and inflammatory skin diseases) and thus has attracted considerable attention as a drug target. The gene encoding for human CXCR3 is localized in the chromosomal region Xq13. | | | Catalog # | C8349-05A | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:100-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.025% sodium azide, 50% glycerol. | | Purity | Serum | | Immunogen | Synthetic peptide corresponding to aa24-37 (SSSYDYGENESDSC) of human CXCR3 (CXC Chemokine Receptor 3). | | Specificity | Recognizes human CXCR3. Species sequence homology: canine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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