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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -CXCR3 (C-X-C Chemokine Receptor Type 3, CXC-R3, CXCR-3, CKR-L2, G Protein-coupled Receptor 9, Interferon-inducible Protein 10 Receptor, IP-10 Receptor, CD183, GPR9)

Anti -CXCR3 (C-X-C Chemokine Receptor Type 3, CXC-R3, CXCR-3, CKR-L2, G Protein-coupled
Receptor 9, Interferon-inducible Protein 10 Receptor, IP-10 Receptor, CD183, GPR9)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10, Mig and I-TAC. The protein is mainly expressed on activated Th1 cells, B cells and natural killer cells. It is activated by the interferon-gamma-inducible chemokines CXCL9, CXCL10 and CXCL11, with CXCL11 having the highest affinity. Upon activation, CXCR3 activates pertussis toxin-sensitive G proteins of the Galphai class and mediates, among others, chemotaxis, calcium flux and activation of kinases such as p44/p42 MAPK and Akt. The protein and its ligands are upregulated in a wide variety of inflammatory diseases, implying a role for CXCR3 in serious disorders (e.g. rheumatoid arthritis, multiple sclerosis, transplant rejection, atherosclerosis and inflammatory skin diseases) and thus has attracted considerable attention as a drug target. The gene encoding for human CXCR3 is localized in the chromosomal region Xq13.
Catalog #C8349-05A
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa24-37 (SSSYDYGENESDSC) of human CXCR3 (CXC Chemokine Receptor 3).
SpecificityRecognizes human CXCR3. Species sequence homology: canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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