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Anti -CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)
Anti -CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
B IH IC |
|
| CXCR4, also termed Fusin, LESTR, or HUMSTR is a member of the G-protein-coupled chemokine receptor family with seven membranespanning domains and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CXCR4 is expressed predominantly on naïve T cell subset of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. It is also expressed on neutrophils, monocytes and various cell lines. | | | Catalog # | C8350-08 | | Applications | Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry and Functional Application. Other applications not tested. | | Recommended Dilution | Immunocytochemistry (Acetone fixed cells): 1:300 | | Immunohistochemistry (Paraffin sections): 1:200 | | Western Blot: 1:1000 | | Functional Application: Blocks SDF mediated stimulation of DU-145 cells | | Optimal dilutions to be determined by the researcher. | | Recommended Positive Controls | Human peripheral blood cells (Immunocytochemistry) | | Human spleen cells (Paraffin) (Immunohistochemistry) | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | ~2mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa 13-38 (CT[13]EEMGSGDYDSMKEPCFREENANFNK[38]) of the N-terminal extracellular domain of human CXCR4 (CXC chemokine receptor 4). | | Specificity | Recognizes human CXCR4. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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