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You are here:Home » Antibodies » Antibodies-Receptors » Anti -CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)

Anti -CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)


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Clone Host Grade Applications
Polyclonal Goat Affinity Purified B IH IC
CXCR4, also termed Fusin, LESTR, or HUMSTR is a member of the G-protein-coupled chemokine receptor family with seven membranespanning domains and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CXCR4 is expressed predominantly on naïve T cell subset of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. It is also expressed on neutrophils, monocytes and various cell lines.
Catalog #C8350-08
ApplicationsSuitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry and Functional Application. Other applications not tested.
Recommended DilutionImmunocytochemistry (Acetone fixed cells): 1:300
Immunohistochemistry (Paraffin sections): 1:200
Western Blot: 1:1000
Functional Application: Blocks SDF mediated stimulation of DU-145 cells
Optimal dilutions to be determined by the researcher.
Recommended Positive ControlsHuman peripheral blood cells (Immunocytochemistry)
Human spleen cells (Paraffin) (Immunohistochemistry)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa 13-38 (CT[13]EEMGSGDYDSMKEPCFREENANFNK[38]) of the N-terminal extracellular domain of human CXCR4 (CXC chemokine receptor 4).
SpecificityRecognizes human CXCR4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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