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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184) (PE)

Anti -CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184) (PE)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Purified FC
The G-protein-linked seven transmembrane spanning chemokine receptor CXCR4 (also known as fusin or LESTR) binds stromal cell-derived factor-1 (SDF-1)/CXCL12. CXCR4 also acts as a co-factor for the T-cell tropic HIV-1 and -2 virus entry into cells. In the mouse, two CXCR4 isoforms are generated by alternative splicing resulting in two receptors that differ only in two added amino acids in the N-terminus of the longer CXCR4B protein. The shorter CXCR4A protein is the homolog of human CXCR4. Differential expression of the two isoforms has been reported in lymphoid tissues and brain. Expression of CXCR4 is detected very early in thymocyte differentiation and on double positive thymocytes. In contrast to human CXCR4, mitogenic stimulation leads to the increased expression of CXCR4 on mouse T cells.
Catalog #C8350-09
ApplicationsSutiable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: 10ul labels 1x10e5 cells
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable for 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No7H54
HostRat
SourceMouse
Concentration~0.025mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% sodium azide. Labeled with R. Phycoerythrin (RPE)
PurityPurified
ImmunogenMouse CXCR4
SpecificityRecognizes mouse CXCR4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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