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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)

Anti -CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH FC N
CXCR4, also termed Fusin, LESTR, or HUMSTR is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CXCR4 is expressed predominantly on naïve T cell subset of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. It is also expressed on neutrophils, monocytes and various cell lines.
Catalog #C8375-01E
ApplicationsSuitable for use in Blocking/Neutralization, Flow Cytometry and Immunohistochemistry. The antibody will neutralize human cell surface CXCR4 mediated bioactivity. Other applications not tested.
Recommended DilutionBlocking/Neutralization: 50-200 molar excess
Flow Cytometry: 1:10-1:1000
Immunohistochemistry (Frozen): 1:10-1:2000
Immunohistochemistry (Paraffin): 1:10-1:2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No8J1097
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 5% trehalose.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman CXCR4 transfected mouse 3T3 cells. Cellular Localization: Cell membrane
SpecificityRecognizes human CXCR4 (fusin) transfected cells and not with the parent cell line by Flow Cytometry. Shows no crossreactivity with other chemokine receptors. Antibody will neutralize human cell surface CXCR4 mediated SDF/PBSF response using human cultured lymphocytes in a chemotaxis assay. Species Crossreactivity: Human and Feline. Does not crossreact with Rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCD184, Chemokine CXC Motif Receptor 4, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3, NPYY3R, Probable G protein coupled receptor lcr1 homolog, WHIM


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