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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -CXCR4 (C-X-C Chemokine Receptor Type 4, Chemokine (C-X-C Motif) Receptor 4, CXC-R4, CXCR-4, CD184, D2S201E, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, Leukocyte-derived Seven Transmembrane Domain Receptor, LESTR, NPYR, NPY3R, NPYRL, NPYY3R, Stromal Cell-deriv

Anti -CXCR4 (C-X-C Chemokine Receptor Type 4, Chemokine (C-X-C Motif) Receptor 4, CXC-R4,
CXCR-4, CD184, D2S201E, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, Leukocyte-derived Seven
Transmembrane Domain Receptor, LESTR, NPYR, NPY3R, NPYRL, NPYY3R, Stromal Cell-deriv

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
CXCR4, a Chemokine Receptor involved in organ vascularization, neuronal cell migration, and patterning of the central nervous system during development. It binds stromal cell-derived factor 1 (SDF1, also called PBFS) and mediates migration of resting leukocytes and is unique in homing hematopoietic progenitors to bone marrow. These properties suggest that CXCR4 is involved in tumor cell migration and local tumor invasion. It is also an HIV-1 fusion co-factor that allows HIV-1 invasion in diverse Human cell types. Although this receptor was initially called Neuropeptide Y3 Receptor, it does not respond to neuropeptide Y. CXCR4 has two isoforms that are produced by alternative splicing. CXCR4 has been reported to be expressed in cells of the immune and central nervous systems. It is highly expressed in brain and heart, and in white blood cells, vascular endothelial cells, and umbilical cord endothelial cells. In brain tumors, CXCR4 is expressed in regions of angiogenesis and degenerative, necrotic, and microcystic changes (Rempel et al., 2000). ESTs have been isolated from a wide variety of tissue libraries, particularly uterus, kidney, lung, tonsil, and brain.
Catalog #C8375-01L
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 9-14ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman Brain, Neurons and glia
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the 3rd cytoplasmic domain of human CXCR4.
SpecificityRecognizes uman CXCR4. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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