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You are here:Home » Antibodies » Abs to G Protein Receptors » Anti -CXCR7 (G-protein Coupled Receptor 159, Chemokine Orphan Receptor 1, G-protein Coupled Receptor RDC1 Homolog, RDC-1, C-X-C Chemokine Receptor Type 7, CXC-R7, CXCR-7, CMKOR1, GPR159, RDC1) (APC)

Anti -CXCR7 (G-protein Coupled Receptor 159, Chemokine Orphan Receptor 1, G-protein
Coupled Receptor RDC1 Homolog, RDC-1, C-X-C Chemokine Receptor Type 7, CXC-R7, CXCR-7,
CMKOR1, GPR159, RDC1) (APC)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
The G protein-coupled receptor RDC-1 belongs to a subgroup of chemokine receptors and has been designated CXCR7. CXCR7 can bind with high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC. It is also a co-receptor for several HIV and SIV strains. In their N-termini and extracellular loops 1, 2, and 3, human and mouse CXCR7 share 84%, 100%, 96% and 86% aa sequence identity, respectively. Reports of mRNA levels and/or protein expression (as assessed using anti-CXCR7, clone 9C4) indicate that CXCR7 occurs on a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells. In contrast, based on ligand binding and receptor level analyses (as assessed using C8376-25A), surface expression of CXCR7 was reported to be restricted primarily to tumor cells, activated endothelial cells, and fetal liver cells. The basis of these inconsistent observations is not known but may be attributed to cell context and the use of different antibodies that may recognize different epitopes.
Catalog #C8376-25A
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionsFlow Cytometry: 10ul labels 1-2.5x10e5 cells.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C. Stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing Allophycocyanin conjugates will result in a substantial loss of eactivity. APC is light sensitive.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11C11
HostMouse
SourceHuman
Concentration~0.01mg/ml
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
PurityPurified by Protein G affinity chromatography.
ImmunogenPlasmid encoding human CXCR7/RDC-1 (hCXCR7/RDC-1; Accession # P25106).
SpecificityRecognizes human CXCR7.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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