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You are here:Home » Antibodies » Abs to G Protein Receptors » Anti -CXCR7 (G-protein Coupled Receptor 159, Chemokine Orphan Receptor 1, G-protein Coupled Receptor RDC1 Homolog, RDC-1, C-X-C Chemokine Receptor Type 7, CXC-R7, CXCR-7, CMKOR1, GPR159, RDC1)

Anti -CXCR7 (G-protein Coupled Receptor 159, Chemokine Orphan Receptor 1, G-protein
Coupled Receptor RDC1 Homolog, RDC-1, C-X-C Chemokine Receptor Type 7, CXC-R7, CXCR-7,
CMKOR1, GPR159, RDC1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH FC N
CXCR7/RDC1 is a 362aa CXC chemokine receptor involved in a number of pathobiologic processes, including cell growth, survival and adhesion, and tumor growth. It belongs to the G-protein coupled receptor 1 family. Though CXCR7 was previously identified as a receptor for vasoactive intestinal peptide (VIP), it is now considered as an orphan receptor in that its endogenous ligand has not been identified. It is an alternative receptor for CXCL12/SDF1 and ITAC (CXCL11) as well as acts as a co-receptor with CXCR4 for a restricted number of HIV isolates. Reports suggest that CXCR7 may act as a link between inflammation and cancer. This membrane protein is usually expressed in monocytes, basophils, and B-cells while low expression is also seen in CD4+ T-lymphocytes and natural killer cells.
Catalog #C8376-25L
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Neutralization and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 4-6ug/ml
Immunohistochemistry (formalin fixed paraffin embedded): 10ug/ml
Flow Cytometry (Cell surface): 1-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide (QHNQWPMGELTC) corresponding to aa106-117 of human CXCR7, NP_064707.1.
SpecificityRecognizes human CXCR7. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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