Anti -CXCR7 (G-protein Coupled Receptor 159, Chemokine Orphan Receptor 1, G-protein
Coupled Receptor RDC1 Homolog, RDC-1, C-X-C Chemokine Receptor Type 7, CXC-R7, CXCR-7,
CMKOR1, GPR159, RDC1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH FC N |
|
| CXCR7/RDC1 is a 362aa CXC chemokine receptor involved in a number of pathobiologic processes, including cell growth, survival and adhesion, and tumor growth. It belongs to the G-protein coupled receptor 1 family. Though CXCR7 was previously identified as a receptor for vasoactive intestinal peptide (VIP), it is now considered as an orphan receptor in that its endogenous ligand has not been identified. It is an alternative receptor for CXCL12/SDF1 and ITAC (CXCL11) as well as acts as a co-receptor with CXCR4 for a restricted number of HIV isolates. Reports suggest that CXCR7 may act as a link between inflammation and cancer. This membrane protein is usually expressed in monocytes, basophils, and B-cells while low expression is also seen in CD4+ T-lymphocytes and natural killer cells. | | | Catalog # | C8376-25L | | Applications | Suitable for use in Flow Cytometry, Western Blot, Neutralization and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 4-6ug/ml | | Immunohistochemistry (formalin fixed paraffin embedded): 10ug/ml | | Flow Cytometry (Cell surface): 1-10ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide (QHNQWPMGELTC) corresponding to aa106-117 of human CXCR7, NP_064707.1. | | Specificity | Recognizes human CXCR7. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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